By far the hardest problem to finish in Resident Evil: Requiem is The Last Puzzle, and the proof is the truth that no one appears to have cleared it in its entirety but.
The Last Puzzle is a posh, obtuse, multi-step problem that asks you to know the distances between Earth and celestial our bodies, rotate seemingly ineffective gadgets, and way more. We don’t totally perceive it but – it appears no one does however the builders – however we’re breaking down all the things that the neighborhood has managed to uncover to date.
Have an excellent take into consideration all of the steps and data we record on this information, and possibly you’ll be the one to assist us clear up Resident Evil: Requiem’s The Last Puzzle.
The Last Puzzle begin, the Severed Hand – RE9 Requiem
We have already got a brief information on methods to use the Severed Hand, however we’ll provide the abridged model right here.
Scanning the Severed Hand with the Blood Evaluation Machine in both the Blood Lab or the Workplace will activate a novel puzzle, together with a message that reads: “Let’s play.” It additionally offers you an mRNA sequence that reads as follows:

For those who convert this strand right into a Protein, it reads as follows
Which implies nothing, until we take the primary letter of every part, after which we now have GLITCH.
Does this imply something? Really, it could possibly be a pink herring, as a result of there’s one other use for the code, however first we now have to decrypt it.
The Last Puzzle cypher defined – RE9 Requiem
It’s an mRNA code, certain, however there’s truly one other use for it, and the primary trace we observed was on the Hourglass merchandise. Whenever you study the Hourglass and rotate it, you’ll see that below the sand is the next message:

A bit unusual, however we’ve seen the same message earlier than. On the Blood Evaluation Machine within the Blood Lab:

Lastly, for those who have a look at the Grace Ashcroft Blood Evaluation Report File within the Courtyard Lab, you’ll see this last message:

The “ly” is the trace that ties all the things else collectively. Every little thing else on this file is a “Match,” the ultimate message stands out as being by some means incorrect or misplaced. However for those who’re accustomed to astronomy, you may know that Alpha Centauri, the closest star system to Earth, is roughly 4.2 light-years away. Because of Synth Potato for being the primary individual we all know of to determine this out.
Immediately, you’ll be able to translate this message as C = Star. With that data, we return to the earlier messages, and we see that 380,000 is the gap to the Moon in kilometres, so U = Moon. For those who’re accustomed to the themes of the Care Middle, you’ve in all probability additionally discovered that G = Solar, as 150000000 is the gap to the Solar in miles.
A is the outlier, however a really unusual easter egg tells us to disregard this one — due to IGN for locating this. You’ll be able to kick the pinnacle of the Toy Uncle Bobblehead – a shootable mascot from Resident Evil 3 – across the basketball court docket after Leon’s combat with the Tyrant, and kicking it by means of the basketball hoop will provide you with the message “There’s no time for taking part in round.” As soon as once more, play is talked about. Verify the Toy Bobblehead torso in Gun Store Kendo after, and also you’ll be given the message to “Simply ignore A.” And that’s what we’re going to do.
To summarise the cypher:
- U = Moon
- G = Solar
- C = Star
- A = Ignore
Lead Researcher’s Workplace Puzzle Field code – RE9 Requiem

If we have a look at the mRNA message from the Blood Evaluation Machine once more, ignore A, after which substitute the letters with the celestial our bodies they characterize, we find yourself with this message:
- SUN, SUN, STAR, SUN, MOON, STAR, SUN, MOON, SUN, MOON, STAR, MOON.
Head to the Lead Researcher’s Workplace within the Care Middle, and enter that code on the Quartz Puzzle Field machine within the room. Whenever you’ve carried out it accurately and backed away from the machine, you’ll hear a laughter audio cue play from a number of rooms away.
That is the place the concrete data on methods to clear up the puzzle ends, however we do have a couple of leads.
The Last Puzzle potential answer, mysteries – RE9 Requiem
As soon as once more, Synth Potato has led the cost on getting this thriller solved and is sharing data discovered by participant GengarCollects. GengarCollects claims to have picked up the merchandise Marie’s Doll when escaping from the Courtyard Lab, and dataminers have confirmed that this merchandise does, in reality, spawn within the precise place that GengarCollects claimed, however we nonetheless don’t know precisely what makes it spawn there.
What we do know is that GengarCollects claims that coming into the code we talked about above into the Lead Researcher’s puzzle field with Marie’s Doll in his stock solved the puzzle and accomplished the problem.

However that’s not the one thriller at play right here. It’d look like the answer is in sight, however there are nonetheless questions that have to be answered. A type of includes the Hourglass, and one of many areas from Grace’s intro in Wrenwood’s metropolis streets.
As proven by Milmilk_YouTube, analyzing the Hourglass in Marie’s cell within the Treatment Room whereas dealing with the opening within the wall truly uncovers a message which appears to say: “CO’S”
As of proper now, Milmilk_YouTube and different customers assume this pertains to Nico’s, a sandwich store Grace passes close to the start of the sport. Additionally famous by Milmilk is that a few of Grace’s loss of life animations by the hands of The Woman – who’s Marie, horrifically mutated – have her watching Grace’s watch. Is that this associated? Completely something could possibly be at this level.
A pressured The Last Puzzle answer – RE9 Requiem
Despite the fact that there are nonetheless some unusual mysteries within the sport that also have to be solved, plainly a pair of gamers on YouTube, Kyro and Rantsycancy, have lastly solved The Last Puzzle, however they’ve carried out it with data gleaned from datamining.
This makes use of a mixture of flag manipulation within the Care Middle Basement’s Processing Room and a few uncommon bathroom flushing habits. For the total breakdown, be certain to look at the embedded video, however for now, we’re satisfied that there’s a extra “pure” strategy to clear up The Last Puzzle.
